HOW TO DOSE WITH PHENTERMINE SCHEDULE

Phentermine- Related Weight Loss Drugs: Long-Term Safety for Treatment of Obesity

Table of Contents

Phentermine: Safe and Effective for More than 65 Years!

Phentermine-Adipex 37.5 mg Diet Pill including phentermine HCL and 30 mg phentermine have been prescribed for initial weight loss and weight control successfully for more than 50 years in the United States. In fact, Adipex and phentermine are the most prescribed medications used for weight control. Recent data from 2016 show that it’s the 226th most commonly prescribed medication with over 4 million prescriptions filled per year. Phentermine for weight loss mechanism of action is thought due to appetite suppression through norepinephrine release and to a lesser extent through dopamine and serotonin release from multiple centers in the brain

Phentermine: Often Maligned Because It Has a Similar Chemical Structure and Side Effects of the Amphetamines

Often maligned inappropriately because its two-dimensional structure resembles amphetamine and because of similar side effects, it remains the safest and most effective oral medication available for the long-term treatment of obesity. It is far safer than the disease it is used to treat. Almost all the controversy surrounding phentermine was (and still is for some individuals) surrounding safety and effectiveness. Phentermine on line has helped hundreds of patients who are unable to get the medication locally.

It has been in active use since its initial approval by the FDA in 1959. The first re-evaluation was in 1973, when the FDA evaluated all drugs for not only safety but also effectiveness. It passed all the tests. The first long-term study was released in 1968. It reported on 108 obese women treated for more than 8 months. An average weight loss of 13% was found on phentermine and the only side effects noted were dry mouth, insomnia, and constipation all which proved unimportant.

Note how closely the phentermine and amphetamine molecules appear. Only a slight change. Yet both drugs have different actions. A few of the side effects are similar but they act quite differently.

Phentermine Tolerance Breaks: How Long?

Phentermine in the form of 15, 30, and 37.5 mg doses has been on the market for more than 60 years. Twenty years ago, it was felt that the development of tolerance to weight loss could be avoided by taking “tolerance breaks.” This was accomplished by stopping the drug for 2-3 weeks after a 6-8 week treatment period. Some clinicians suggested taking the medication with 2 or 3-day breaks as another method. However, recent research from the NIH has found NO benefit and NO increased weight loss by taking tolerance breaks. A large long-term study from Mexico found similar results.

Fifty Years of Studies of Phentermine: Safety and Effectiveness and Phentermine Side Effects

Phentermine-Adipex 37.5 mg Diet Pill, unlike most medications, has been re-evaluated on more than four occasions over the past 50 years! Phentermine 30 mg has had less attention. The first and most notable occurred during the phen/fen crisis of 1997. After several years and evaluation of thousands of patients across the country, phentermine was found to be both safe and effective. The occurrence of pulmonary hypertension and valvular heart disease was found to be due to the serotonin drug fenfluramine, part of the phen/fen combination, which was then taken off the market. Since that time, there have been no reports linking pulmonary hypertension and valvular heart disease with any anorectic medication. This re-evaluation cleared up the issue of phentermine effectiveness and safety.

Phentermine, a 50 year old medication produces safe and effective weight loss over a year

Phentermine in Combination: The Most Extensive Evaluation of Any Weight Loss Medication in 2010-2019

The FDA re-evaluated the side effects and effectiveness for long-term obesity treatment when it approved a new medication, Qsymia, a combination of various doses of phentermine and topiramate. The FDA reviewed the results of 4500 obese people treated with different dose combinations of the two medications for 12 to 36 months. Again, it was found safe and effective with a 9 to 12% weight loss.

Cardiovascular Safety Tested

To ensure safety, the FDA required a separate study of possible cardiovascular side effects: twelve hundred obese patients followed to examine the occurrence of any cardiovascular complications, including changes in blood pressure, heart rate, and cardiac echoes. No abnormalities were found. There was no elevation in blood pressure, contrary to popular opinion. This has been the experience of nearly all physicians treating obese people, even those with concurrent hypertension. The most recent report on the long-term safety of phentermine was released in 2019. It consisted of multiple studies over many years and stressed safety with long-term use and for maintenance of weight loss.

Lomaria-Phentermine Low Dose for Multiple Doses Daily 2016:

The most recent FDA evaluation occurred in 2016 when the FDA approved phentermine hydrochloride in an 8 mg dose, a low-dose medication for adults with obesity that is taken up to three times daily. This was named Lomaria. This new dosage form involves a short-acting medication taken before meals or whenever the patient is hungry, up to 4 hours before sleep. It fills in the gap between the long-acting 12-hour effect of the 37.5mg extended-release phentermine.https://www.healio.com › endocrinology › obesity › news › online › fda-app…

Phentermine Reports of Long-Term Use: Safety Studies 2002-2021

Despite the global epidemic of obesity, only a handful of drugs have been developed and approved by the FDA in the past 30 years, and 2 have been taken off the market. This compares to more than 700 drugs approved for diabetes, heart disease, and neurological disease! The difficulty has been not only the many causes of obesity, but also the high recurrence after weight loss, as well as the need for safe medications for a very long time. Since only two medications are effective for long-term use– orlistat and phentermine, many studies have been done to establish the effectiveness and safety of these medications. Phentermine is the most effective. Three studies of phentermine offer the most information:

2002 – Dr. C.K. Haddock: Dr. Haddock reported on 108 clinical trials of anorectic agents from 1976 through 2002. The study included short and long-term results and follow-up. He found that 43% of phentermine-treated patients maintained at least 80% of their initial weight loss compared to 15% of placebo-treated patients.

2018 – The Pennington Biomedical Center reported in Clinical Chemistry in 2018. The authors reported results from multiple centers across the US covering all 9 medications. The best results were the 6% weight loss above the placebo for phentermine. They reported no evidence of significant side effects, especially hypertension and cardiovascular disease.

More Recent Reports of Phentermine Safety

2019 review of 13,972 Phentermine Users: The most robust review to date of phentermine was reported by Dr. Khristina Lewis’ team, which analyzed 13,972 adults in the Journal of Obesity treated with phentermine for up to three years. “In general, the longer patients were on the medicine, the more weight loss they had,” Lewis said. “Not surprisingly, when patients stopped taking the medicine, weight regain was common.” Dr. Lewis found long-term use was not associated with increases in blood pressure or increased risk of heart attack, stroke or death but was associated with significant and progressive weight loss across almost all users.

2021 Phentermine study from Mexico: This study of 932 obese individuals revealed 1“ tolerance of less than 10% with 65% of patients reaching the goal of 5-7 % weight loss. No phentermine breaks were felt necessary.

Read more about phentermine–clinical usage, side effects, doses, probably the best diet pill of all times.